Figure 6: β3-AR agonism increases lipolytic processing and hepatic clearance of lipoproteins in E3L.CETP mice.
From: Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
β3-AR agonist CL316243- and vehicle-treated mice were injected with VLDL-like particles, double-labelled with glycerol [3H]TO and [14C]CO, and (a,c) clearance from plasma as well as (b,d) uptake by organs and tissues at 15 min after injection were determined for (a,b) 3H-activity and (c,d) 14C-activity. The hepatic uptake of 14C activity was plotted against the uptake of [3H]TO-derived activity in (e) interscapular brown adipose tissue (intBAT), (f) subscapular BAT (subBAT) and (g) perivascular adipose tissue (pVAT). Linear regression analyses were performed. Values are means±s.e.m. (n=5–7 per group). *P<0.05, **P<0.01, ***P<0.001 (unpaired two-tailed Student’s t-test).
