Figure 6: Npn1 and Npn2 invalidation alters the orientation of neural progenitor divisions at E10.5. | Nature Communications

Figure 6: Npn1 and Npn2 invalidation alters the orientation of neural progenitor divisions at E10.5.

From: Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis

Figure 6

(a) Confocal images showing immunolabelling of Npn1 and Npn2 on spinal cord sections at E10.5. Npn1 and Npn2 proteins are distributed in complementary domains of the VZ. Ctrl-immunostaining without primary antibody. (b) Cumulative fraction curves showing the distribution of neural progenitor division orientation in E10.5 Npn1sema/+;Npn2+/− and Npn1sema/sema;Npn2−/− spinal cords (n, number of cells from a minimum of three embryos per conditions from the same litters, P value is from the KS test). The cumulative curve of the E10.5 Sema3B+/+condition has been added for comparison. Previous data sets are also displayed in pie charts (P value is from Fisher’s exact test).

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