Figure 2: IRF8 binds to the promoters of autophagy genes. | Nature Communications

Figure 2: IRF8 binds to the promoters of autophagy genes.

From: IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes

Figure 2

(a) Consensus IRF8-binding motifs are shown in bold on indicated autophagy gene promoters. (b) IRF8 binding to the above motifs was detected by ChIP for WT and Irf8−/− MФs (UT or treated with IFNγ/TLR) normalized by normal IgG binding, and with β-globin as a negative control. Values represent the average of five independent experiments. *P≤0.05 and **P≤0.01. (Student’s t-test). (c) Summary of qRT-PCR analysis rescue experiment and ChIP assays.

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