Table 1 Twelve reported SNPs that met the validation criteria, 11 of which were included in the following validation.

Cytoband	Published SNPs*	Ref	P _published ^†	Tag SNP ^‡	P _our ^§	Validated SNPs
1p31.1	rs1417437	39	3 × 10⁻⁶	rs227115	3.50 × 10⁻²	rs1417437
1p22.1	rs560426	12	3 × 10⁻¹²	rs560426	1.24 × 10⁻²	rs560426
1q32.2	rs10863790	10	1 × 10⁻¹⁴	rs10863790	1.90 × 10⁻⁸	rs2235371
1q32.2	rs642961 (rs861020)	12	3 × 10⁻¹²	rs861020	1.61 × 10⁻⁵	rs674433
2p24.2	rs4441471	12	8 × 10⁻⁷	rs10856790	4.34 × 10⁻⁴	rs4441471
2q35	rs3815854	12	7 × 10⁻⁶	rs16860316	3.99 × 10⁻⁴	rs3815854
8q21.13	rs7820074	12	9 × 10⁻⁶	rs11774876	4.49 × 10⁻³	rs7820074
8q21.3	rs12543318	12	2 × 10⁻⁸	rs2337161	3.37 × 10⁻⁴	rs12543318
10q25.3	rs7078160	9,12	4 × 10⁻¹¹	rs10510026	1.05 × 10⁻⁵	rs7078160
13q12.12	rs17079928	39	6 × 10⁻⁶	rs17079928	2.53 × 10⁻²	rs17079928
17q22	rs227731	9,12	1 × 10⁻⁸	rs227731	7.27 × 10⁻⁴	rs227731
20q12	rs13041247	12	6 × 10⁻⁹	rs6072084	2.01 × 10⁻³	rs13041247

GWAS, genome-wide association study; LD, linkage disequilibrium; SNP, single-nucleotide polymorphism.
^*SNPs from GWAS catalogue (search key word: cleft lip).
^†P values of published SNPs from GWAS catalogue.
^‡For SNPs without data in initial GWAS scan, we selected tag SNPs that were in LD with published SNPs (r²>0.8).
^§P value from meta-analysis of two cohorts in the initial discovery phase (logistic regression).

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