Figure 7: Leukocyte rolling is increased in endothelial-specific S1P1 knockout mice (S1P1 SCL-Cre-ERT).
From: Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
(a) Leukocyte rolling was quantified in postcapillary venules of the cremaster muscle of S1P1 SCL-Cre-ERT mice (Cre+ and Cre−, n=9 per group). Rolling was also measured after systemic injection of a P-selectin-blocking antibody (n=4 per group). (b) Leukocyte rolling after administration of 1.25 mg kg−1 i.p. FTY720 30 min before the experiment in both genotypes (Cre+ n=4, Cre− n=3). Quantitative data are presented as mean±s.e.m. Significance was established using a Wilcoxon rank sum test. *P<0.05; *P<0.05; ***P<0.001.
