Table 1 Univariate and multivariate analysis of factors associated with fibrosis stage ≥2 in 3,129 patients with CHC.
From: Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Variables | Fibrosis <2 | Fibrosis ≥2 | Univariate analysis | Multivariate analysis | |
|---|---|---|---|---|---|
(n =1,584) | (n =1,545) | P- value | OR (95% CI) | P- value | |
Age at time of biopsy (years) | 42 (18–62) | 47 (18–69) | <0.0001* | 1.03 (1.02–1.05) | <0.0001 |
Male (%) | 944 (47.7) | 1036 (52.3) | <0.0001† | 1.35 (1.19–1.59) | <0.0001 |
Alcohol intake (%) | |||||
None or <50 g daily (%) | 1373 (51.2) | 1310 (48.8) | 0.1† | — | — |
≥50 g daily (%) | 211 (47.3) | 235 (52.7) | |||
HCV genotype | |||||
HCV-3 (%) | 231 (46.3) | 268 (53.7) | 0.03† | 1.21 (1.01–1.48) | 0.03 |
Non-HCV-3 (%) | 1353 (51.4) | 1277 (48.6) | |||
BMI (kg m−2) | 25.3 (16–46) | 26 (16–46) | <0.0001* | 1.002 (0.999–1.004) | 0.1 |
ALT (IU l−1) | 60 (12–596) | 86 (12–916) | <0.0001‡ | 1.003 (0.941–1.32) | 0.2 |
AST (IU l−1) | 45 (11–678) | 64 (11–678) | <0.0001‡ | 1.19 (1.11–1.45) | 0.001 |
ALP (IU l−1) | 81 (10–902) | 90 (14–1018) | 0.001‡ | 1 (0.996–1.004) | 0.9 |
Bilirubin (mg dl−1) | 0.63 (0.1–4.71) | 0.68 (0.1–4.72) | <0.0001‡ | 1.34 (0.85–2.1) | 0.2 |
GGT (IU l−1) | 41 (7–581) | 61 (7–851) | <0.0001‡ | 1.14 (1.003–1.23) | 0.01 |
Platelet (× 109 l−1) | 224 (54–577) | 187 (43–674) | <0.0001‡ | 0.993 (0.990–0.996) | 0.0001 |
HCV-RNA log10 (IU l−1) | 5.92 (2.4–7.95) | 5.9 (2.51–7.84) | 0.8‡ | — | — |
rs12979860 | |||||
CC (%) | 485 (43) | 642 (57) | <0.0001† | 1.63 (1.24–2.51) | <0.0001 |
CT/TT (%) | 1099 (54.9) | 903 (45.1) | |||
Inflammation score | |||||
None/mild (%) | 1138 (65.5) | 637 (34.5) | <0.0001† | 3.43 (3.13–4.22) | <0.0001 |
Moderate severe (%) | 446 (31.5) | 908 (68.5) | |||
Steatosis degree | |||||
None/mild (%) | 1295 (50.5) | 1266 (49.5) | 0.8† | — | — |
Moderate severe (%) | 289 (50.9) | 279 (49.1) | |||
