Table 2 rs6137473 association results in all data sets.

From: A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Study

Risk allele

Females

Males

Combined

  

P

OR (95% CI)

P

OR (95% CI)

P

Stage I

G

2.36 × 10−7

1.64 (1.36–1.98)

0.67

1.09 (0.75–1.58)

5.58 × 10−7

Stage II

G

0.19

1.16 (0.93–1.45)

0.45

1.21 (0.74–1.97)

0.13

TSRHC III

G

2.40 × 10−4

1.67 (1.27–2.21)

0.73

0.90 (0.49–1.64)

1.50 × 10−3

Japan

G

3.70 × 10−3

1.18 (1.06–1.33)

NA

NA

NA

Combined

 

2.15 × 10−10

1.30 (1.19–1.41)

0.81

1.08 (0.82–1.41)

3.12 × 10−8

  1. CI, confidence interval; NA, data not available; OR, odds ratio; TSRHC, Texas Scottish Rite Hospital for Children.
  2. Results of allelic association tests performed using Cochran Armitage trend test are shown for the case–control studies (Stage I, TSRHC III and Japan). TDT-HET P-values are shown for the family-based study (Stage II).
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