Figure 1: A photolabile inhibitor of HIV-1 PR and its degradation triggered by light.

(a) HIV-1 protease inhibitor Ritonavir; (b) Photodegradable inhibitor of HIV-1 PR (compound 1) and products resulting from photolysis (compound 2 and coumarin derivative). Inhibition constants determined as in Fig. 3a are shown for each compound.