Figure 4: Bmi1 activation blocks development of cardiac hypertrophy.
From: Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence
(a) mRNA levels of Bmi1 in heart samples from nontransgenic control mice (iBmi1tg/tg) and Bmi1 transgenic mice (iBmi1tg/tg;MLC2tg/+; means±s.d.; n=8, *P<0.05; Student’s t-test). (b) HW/BW ratios in iBmi1tg;MLC2 mice and iBmitg littermates 4 weeks after the TAC surgery or sham operation. Data are means±s.d.; n=8 mice per group (means±s.d.; n=6, *P<0.05; Student’s t-test). (c,d) Left ventricular wall thickness and fractional shortening measured using echocardiography in the same hearts as in b. (e) Representative low-magnification views of H&E-stained cross-sections at the midventricle from nontransgenic and Bmi1 transgenic mice subjected to sham or TAC treatment and stained with WGA (top; scale bars, 10 μm) or Masson’s trichrome to detect fibrosis (bottom; scale bars, 40 μm).
