Figure 1: Ainsliadimer A (1) suppresses the production of inflammatory cytokines in vivo.
From: Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine
Chemical structure of ainsliadimer A (1). (b–d) Effects of ainsliadimer A (1) on the production of serum TNF, IL-6 and IL-1β induced by LPS. The mice were administered intravenously with ainsliadimer A (1) (25 mg kg−1) (LPS+ainsliadimer A group), BMS-345541(25 mg kg−1) (LPS+BMS-345541group), Vehicle (LPS+Vehicle group), or PBS(PBS group) for 1.5 h before intraperitoneal injection of LPS (1.6 mg kg−1). Serum concentrations of TNF, IL-6 and IL-1β in the four groups were measured after 3.5 h following LPS injection. Mean±s.e.m. *, P< 0.05 versus PBS; #, P<0.01 versus LPS. For each group, plasma samples were obtained from at least six mice and were analysed in duplicate. Statistical significance was determined by Student’s t-test.
