Table 1 GPC3 cell surface expression and internalization.

From: Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

Cell line

GPC3 sites per cell

Internalized mAb (× 10 3 )/time (h)

  

0.25 h

0.5 h

2 h

4 h

6 h

8 h

G1(A431-GPC3)

1.6 × 106

275

500

1187

3042

5100

5329

Hep3B

2.5 × 105

27

40

68

137

145

152

HepG2

3.2 × 105

28

40

221

401

622

725

Huh-7

9 × 103

1

3

15

24

40

41

SK-Hep-1

Negative

NA

  1. NA, below the detection limit.
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