Figure 3: Regulation of pathways controlling luminal fate commitment by Id4.
From: ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
(a) mRNA expression of Brca1 (n=5/group), Elf5 (n=7/group) and Hey1 (n=7/group) in Comma-D cells over a time course of luminal differentiation in cells overexpressing Id4 or a control. Graphs represent the mean±s.e.m. (b) mRNA expression of Notch pathway components Hey1, Notch1 and Jag1 in mammary glands from 8-week-old Id4−/− mice (n=4) compared with controls (n=5). Graphs represent the mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001, unpaired t-test.
