Figure 3: Genome-wide methylation analysis of pol III-bound Alu DNA. | Nature Communications

Figure 3: Genome-wide methylation analysis of pol III-bound Alu DNA.

From: SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation

Figure 3

(a) Comparison of the fraction of methylation of the indicated Alu subfamilies between genomic DNA (input) and pol III-bound DNA, as determined by ChIP-BS-Seq. The height of a vertical line indicates the fraction methylated at a particular C within the subfamily consensus sequence. (b) Genome-wide comparison of pol III occupancy and DNA methylation of Alu subfamilies. (c) Comparison of the extent of methylation of the AluYa5 subfamily between genomic DNA (input) and pol III-bound DNA. The height of a vertical line indicates the fraction methylated at a particular C within the subfamily consensus sequence. A- and B-block promoter elements are indicated. (d) Pol III occupancy plotted against DNA methylation for Alu SINEs (blue) and tRNA genes (red). Data are plotted as a moving average with 25 data points per window.

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