Table 1 Summary association results for 16 peak cis-miR-eQTLs having supporting GWAS evidence.
From: Genome-wide identification of microRNA expression quantitative trait loci
Peak cis-miR-eQTL | Chr. | miRNAs | Genome context (miRNA) | miR-eQTL FDR | Proxy miR-eQTLs overlap with GWAS SNPs | GWAS traits | GWAS P value | Trait signature miRNAs |
|---|---|---|---|---|---|---|---|---|
rs7607369 | chr2 | miR-26b-5p | Intron (CTDSP1) | 1.2e−5 | rs1541777 | Height | 8.6e−9 | — |
rs2241527 | Severe statin-induced myopathy | 1.3e−6 | — | |||||
rs17572485 | Kawasaki disease (with coronary artery lesions) | 6.4e−6 | — | |||||
rs13165104 | chr5 | miR-218-5p, miR-218-2-3p | Intron (SLIT3) | 7.6e−121 | rs4282339 | Height | 6.6e−16 | — |
rs9342836 | chr6 | miR-30a-3p | Intron (C6orf155) | 8.3e−28 | rs7349905 | Kawasaki disease | 5.4e−6 | — |
rs11763835 | chr7 | miR-339-3p, miR-339-5p | Intron (C7orf50) | 2.5e−30 | rs6951245 | Total cholesterol | 6.1e−8 | miR-339-3p (P=2.5e−7) |
rs13242526 | LDL cholesterol | 7.7e−6 | — | |||||
rs1839612 | chr7 | miR-550a-3p | Intron (ZNRF2) | 2.3e−6 | rs2060708 | White blood cell count (WBC) | 3.9e−6 | — |
rs7789194 | chr7 | miR-148a-3p | Intergenic | 5.8e−3 | rs6951827 | Triglycerides | 7.9e−7 | — |
rs17747335 | chr8 | miR-598 | Intron (XKR6) | 7.0e−5 | rs2244648 | Triglycerides | 3.0e−7 | miR-598 (P=0.032) |
rs7836059 | Systemic lupus erythematosus (SLE) (females) | 4.0e−10 | — | |||||
rs10090800 | Second to fourth digit length ratio | 5.3e−6 | — | |||||
rs28640110 | chr9 | miR-204-5p | Intron (TRPM3) | 2.6e−18 | rs2993008 | Common variable immunodeficiency (Splenectomy) | 2.5e−6 | — |
rs2370747 | chr11 | miR-100-5p, miR-125b-5p | Intergenic | 1.8e−130 | rs7115089 | Total cholesterol | 3.2e−10 | miR-125b-5p (P=0.005) |
HDL cholesterol | 8.4e−9 | miR-100-5p (P=0.039); miR-125b-5p (P=1.68e−5) | ||||||
LDL cholesterol | 7.6e−6 | — | ||||||
rs7941030 | Multiple sclerosis | 8.2e−6 | — | |||||
rs11042699 | chr11 | miR-483-3p | Intron (IGF2) | 9.6e−4 | rs6578985 | Coronary artery disease (CAD) | 1.6e−6 | — |
rs4905998 | chr14 | miR-127-3p, miR-134, miR-370, miR-376a-3p, miR-382-5p, miR-431-5p, miR-433, miR-329, miR-409-3p, miR-494, miR-411-3p, miR-654-5p, miR-668, miR-543, miR-323a-3p, miR-337-3p | Intergenic | 2.7e−59 | rs6575793 | Age at menarche | 1.7e−10 | miR-376a-3p (P=0.007); miR-382-5p (P=0.046) |
rs7149242 | Platelet count (PLT) | 2.7e−8 | — | |||||
rs2127868 | chr14 | miR-625-5p, miR-625-3p | Intron (FUT8) | 3.6e−6 | rs1269068 | Desialylated Glycan Peak 1/Biantennary nongalactosylated glycans/Glycan Peak 1 | 4.4e−18 | — |
rs1256526 | Type 2 diabetes | 4.7e−6 | miR-625-5p (P=0.035) | |||||
rs28483325 | chr15 | miR-628-3p | Intron (CCPG1) | 8.1e−7 | rs7168869 | Mean corpuscular volume (MCV) | 4.3e−6 | — |
rs2737 | chr17 | miR-152 | Intron (COPZ2) | 3.1e−8 | rs1553754 | Body mass index (BMI) | 2.8e−6 | — |
rs11079828 | Attention-deficit/hyperactivity disorder (ADHD) | 6.5e−6 | — | |||||
rs6504340 | Primary Tooth Development during Infancy (Number of teeth by one year of age) | 6.1e−7 | — | |||||
rs28576121 | chr19 | miR-1270 | Intron (ZNF826P) | 2.1e−50 | rs7251204 | Fasting blood glucose | 4.0e−6 | miR-1270 (P=0.002) |
rs2562664 | Fasting insulin | 8.7e−6 | ||||||
rs373001 | chr22 | miR-130b-5p, miR-130b-3p | Exon (PPIL2) | 1.1e−5 | rs861844 | Myocardial infarction (MI), sudden cardiac arrest in patients with coronary artery disease (CAD) | 5.3e−6 |
