Table 2 Results of the replication stage within the Nagahama Study (n=3,460).

From: Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

 

Discovery trait

Axial length

Spherical equivalent

Corneal curvature

 

rs number

rs11073058

rs4798444

rs200329677

 

Nearby gene

GJD2

RPL6P27

WNT7B

 

Effect allele

T

A

C

Replication trait

EAF

0.473

0.497

0.306

Axial length

β

0.09

0.05

0.13

 

SE

0.03

0.03

0.03

 

P value

2.6 × 10−3

0.07

6.4 × 10−5

 

Meta P value

2.4 × 10−8

2.1 × 10−5

1.0 × 10−8

Spherical equivalent

β

−0.25

−0.01

−0.01

 

SE

0.06

0.06

0.07

 

P value

3.6 × 10−5

0.92

0.91

 

Meta P value

2.7 × 10−9

6.2 × 10−4

0.68

Corneal curvature

β

−0.010

0.015

0.054

 

SE

0.006

0.006

0.006

 

P value

0.08

0.01

4.6 × 10−17

 

Meta P value

0.40

0.14

2.5 × 10−25

  1. Associations that reached genome-wide significance in the meta-analysis are described in bold.
  2. EAF, effect allele frequency.
  3. P values derived using linear regression.