Table 2 Results of the replication stage within the Nagahama Study (n=3,460).
Discovery trait | Axial length | Spherical equivalent | Corneal curvature | |
---|---|---|---|---|
rs number | rs11073058 | rs4798444 | rs200329677 | |
Nearby gene | GJD2 | RPL6P27 | WNT7B | |
Effect allele | T | A | C | |
Replication trait | EAF | 0.473 | 0.497 | 0.306 |
Axial length | β | 0.09 | 0.05 | 0.13 |
SE | 0.03 | 0.03 | 0.03 | |
P value | 2.6 × 10−3 | 0.07 | 6.4 × 10−5 | |
Meta P value | 2.4 × 10−8 | 2.1 × 10−5 | 1.0 × 10−8 | |
Spherical equivalent | β | −0.25 | −0.01 | −0.01 |
SE | 0.06 | 0.06 | 0.07 | |
P value | 3.6 × 10−5 | 0.92 | 0.91 | |
Meta P value | 2.7 × 10−9 | 6.2 × 10−4 | 0.68 | |
Corneal curvature | β | −0.010 | 0.015 | 0.054 |
SE | 0.006 | 0.006 | 0.006 | |
P value | 0.08 | 0.01 | 4.6 × 10−17 | |
Meta P value | 0.40 | 0.14 | 2.5 × 10−25 |