Figure 5: Enhanced lipolysis in adipose tissue of GRmKO mice during fasting.
From: A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling
(a) Expression levels of the indicated mRNA in retroperitoneal fat from 30-week-old male GRf/f and GRmKO mice after fasting for the indicated time periods. Data are normalized to 36B4 mRNA levels and are shown as fold induction to expression levels in fed (0 h) GRf/f mice. Error bars represent mean±s.e.m. (n=8). *P<0.05 determined by two-tailed Student’s t-test for unpaired data. (b,c) Plasma concentrations of free fatty acids (b) and 3-hydroxybutyric acid (3-HBA, c) concentration of 30-week-old male GRf/f (blue) and GRmKO (red) mice after fasting for the indicated time periods. Error bars represent mean±s.e.m. (n=8). *P<0.05 between GRf/f and GRmKO determined by two-tailed Student’s t-test for unpaired data.
