Figure 6: Increased systemic circulation of FGF21 in GRmKO mice during fasting.
From: A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling
(a) FGF21, adiponectin and irisin concentrations in the plasma from 30-week-old male GRf/f and GRmKO mice after fasting for the indicated time periods. Data are shown as boxplots (n=8). Whiskers show the minimum and maximum of all the data, boxes show one standard deviation above and below the mean of the data, and lines inside the boxes show the median of the data. *P<0.05 determined by two-tailed Student’s t-test for unpaired data. (b) Expression levels of FGF21 mRNA in the indicated tissues from 30-week-old male GRf/f and GRmKO mice after fasting for the indicated time periods. Data are normalized to 36B4 mRNA levels and are shown as fold induction to expression levels in fed (0 h) GRf/f mice. Error bars represent mean±s.e.m. (n=8). *P<0.05 determined by two-tailed Student’s t-test for unpaired data.
