Figure 1: Overview of Cryptococcus neoformans transcription factors and strategies for their systematic deletion and phenome-based analysis.
From: Systematic functional profiling of transcription factor networks in Cryptococcus neoformans
(a) Pie chart showing the class and distribution of C. neoformans TFs. Each TF was classified based on the DBDs predicted using Superfamily (http://www.supfam.org/SUPERFAMILY/) and Pfam (http://pfam.xfam.org/) databases or Cryptococcus genome database (http://www.broadinstitute.org). Certain TFs contain multiple DBDs (Supplementary Data 1). (b) Flowchart of the construction of the C. neoformans TF mutant library and in vitro and in vivo phoneme-based analyses.
