Figure 2: Functional impact of loss of all Kalirins or specifically Kal-7 in spinal dorsal horn neurons on pain-related behavior. | Nature Communications

Figure 2: Functional impact of loss of all Kalirins or specifically Kal-7 in spinal dorsal horn neurons on pain-related behavior.

From: A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses

Figure 2

(a) Suppression of Phase II, but not phase I, nocifensive behaviour induced by intraplantar formalin in mice lacking all Kalirins in spinal dorsal horn neurons (SDH-pan Kal−/− mice) (n=7–8 per group). (b) CFA-induced mechanical hypersensitivity represented as area under the curve (AUC) of the entire von Frey stimulus-response curve over von Frey forces 0.04 to 1.4 g tested at various time points post-CFA injection in SDH-pan Kal−/− mice as compared with control littermates (n=8–10 animals per group). (c) Suppression of Phase II nocifensive behaviour induced by intraplantar formalin in mice lacking Kal-7 specifically in spinal dorsal horn neurons (SDH-Kal-7−/− mice) as compared with control littermates (n=8–9 per group). (d) Change in response threshold to mechanical force via von Frey filaments following intraplantar injection of complete Freund’s adjuvant (CFA) (n=10–11 animals per group). (e) CFA-induced mechanical hypersensitivity represented as area under the curve (AUC) of the entire von Frey stimulus-response curve over von Frey forces 0.04 to 1.4 g tested at various time points post-CFA injection (n=10–11 animals per group). In all panels, *P<0.05 as compared with control group; †P<0.05 as compared with basal condition; two-way ANOVA followed by Bonferroni post hoc test. Error bars represent s.e.m.

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