Figure 1
From: eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues
Meta-analysis result for association between gene expression and imputed indels and SNPs. (a) Venn diagram for unique number of genes only mapped by SNP or indel or both. (b) Density curve of heritability of gene expression (H2) explained by the top SNP and indel. Red: H2 of the top indel for the 5,898 genes in a. Green: H2 of the top indel for the 325 genes in a. Blue: H2 of the top SNP for the 5,898 genes in a. Purple: H2 of the top SNP for the 3,186 genes in a. (c) Per cent of probes mapped by eQTL (<5% FDR) by total narrow-sense heritability for 51,190 transcription probes. Probes were categorized by total narrow-sense heritability previously estimated based on the MRCA family panel. The red bar shows the per cent of probes mapped by eQTL using the MRCA LCL data alone with imputation of the 1,000G pilot releases. The blue bar shows the per cent of probes mapped using imputation of 1,000G phase 1 variants in MRCA data set excluding probes with indel as the top eQTL. The dash box on top of the blue bar indicates the per cent of mapped probes before excluding probes with indel as top eQTL. The green bar shows the per cent of probes mapped using imputation of 1,000G phase 1 variants in the MRCA data set. The purple bar shows the per cent of probes mapped using meta-analysis across three tissues excluding the probes with indel as the top associated variants. The orange bar shows the per cent of probes mapped using meta-analysis across three tissues. The numbers on top of each group of bars are the number of probes in each heritability category.
