Figure 2: CASP8-coding exons, protein domains and locations of probes. | Nature Communications

Figure 2: CASP8-coding exons, protein domains and locations of probes.

From: New basal cell carcinoma susceptibility loci

Figure 2

(a) Coding exons of the major transcript variants. The positions of exon 8 and exon 8L are indicated. The transcript variant containing exon 8L is designated ‘NR_’ because the exon 8L sequence contains a stop codon that may render this RNA species susceptible to nonsense-mediated decay. (b) Procaspase-8 protein domains corresponding to exons, from pfam: IPR001875-DED are the DED; IPR011600-Pept_C14_cat corresponds to the peptidase catalytic domains. (c) Location of the probe sequences used on the expression microarrays. The height of the bars corresponds to the relative levels of expression in blood. (d) Location of primer-amplicons used in RT–PCR.

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