Figure 1: Intracellular end of M3 and the M1–M2 linker control desensitization of GABAARs. | Nature Communications

Figure 1: Intracellular end of M3 and the M1–M2 linker control desensitization of GABAARs.

From: The desensitization gate of inhibitory Cys-loop receptors

Figure 1

(a–c) Peak-scaled membrane currents elicited by 10 mM GABA (black line), showing the desensitization phase for the indicated receptor constructs (left column). The recovery phase is omitted for clarity. See Table 1 for values of τw and extent of desensitization (% Des) in all figures. The subunit chimeras are depicted by a colour code: green (α1), red (β2) and grey (ρ1) (right column). Numbering refers to the position of the interface between the two subunits in the chimera. TM/M, transmembrane domain, INT, intracellular loops.

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