Figure 2: Mutating the intracellular end of the M2/M3 interface regulates desensitization of α1β2 GABAARs. | Nature Communications

Figure 2: Mutating the intracellular end of the M2/M3 interface regulates desensitization of α1β2 GABAARs.

From: The desensitization gate of inhibitory Cys-loop receptors

Figure 2

(a) Left: 3D model of an α1β2 GABAAR based on GluCl template. Right in a–c: membrane currents induced by 10 mM GABA. (b) Left: enlarged side view of the intracellular end of the ion channel showing transmembrane domains M1–M3 for α1 (green) and β2 (red) subunits and the positions of various labelled residues. (c) Left: enlarged plan view of the ion channel. Note, in b,c, M4 segments were omitted for clarity.

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