Figure 3: Effects of mutations α1L300Vβ2L296V and α1G258V β2G254V on GABA sensitivity. | Nature Communications

Figure 3: Effects of mutations α1L300Vβ2L296V and α1G258V β2G254V on GABA sensitivity.

From: The desensitization gate of inhibitory Cys-loop receptors

Figure 3

GABA concentration–response curves for wild-type (wt) α1β2 (EC50=4.1±0.7 μM, nH=1.08±0.07, n=6), α1L300Vβ2L296V (EC50=7.3±0.9 μM, nH=0.91±0.02, n=5) and α1G258V β2G254V receptors (EC50=3.0±0.9 μM, nH=0.89±0.19, n=5). Error bars are s.d.

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