Figure 7: GlyR current recovery after blockade by PTX under desensitizing conditions.
From: The desensitization gate of inhibitory Cys-loop receptors
(a) Representative recording of the fast dissociation of PTX from GlyRα1 activated by high concentrations (10 mM) of glycine, accompanied by a clear rebound current (n=5). (b–d) Predicted membrane currents for activated wild-type GlyRα1 using the kinetic models 1–3, respectively, described in Fig. 6. See Supplementary Table 2 for the numerical values of parameters. Note, peak currents are truncated for clarity.
