Table 1 Meta-analyses of neuropeptides.

From: Galanin modulates the neural niche to favour perineural invasion in head and neck cancer

Full name (gene)

N (significant/non-significant studies)

t -test (df)

P value

Galanin (GAL)

16 (6/10)

2.6 (15)

0.01005

Brain-derived neurotrophic factor (BDNF)

16 (4/12)

1.789 (15)

0.025

Neural growth factor (NGF)

16 (3/13)

1.364 (15)

0.0963

Glial cell line-derived neurotrophic factor (GDNF)

12 (2/10)

1.0393 (11)

0.1607

Neurotrophin-3 (NTF3)

16 (2/14)

0.8783 (15)

0.1968

Neuropeptide Y (NPY)

16 (2/14)

0.8783 (15)

0.1968

Peptide YY (PYY)

16 (1/15)

0.2 (15)

0.4221

Vasoactive intestinal peptide (VIP)

16 (1/15)

0.2 (15)

0.4221

  1. These meta-analyses were conducted as one-sample t-tests using the 16 studies shown in Supplementary Table 1 (significance P=0.05). In these analyses: for GAL, all 16 were used; Sengupta, Peng Head Neck 2, TCGA, Ye, Cromer and Pyeon Tongue were significant. For BDNF, all 16 were used; Sengupta, Peng Head Neck 2, Ye and Pyeon Floor of Mouth were significant. For NGF, all 16 were used; Peng, Estilo and Talbot were significant. For GDNF, only 12 were used (four of the studies did not evaluate GDNF levels); Peng Head Neck 2 and TCGA were significant. For NTF3, all 16 were used; TCGA and Peng 2 were significant. For NPY, all 16 were used; TCGA and Peng 2 were significant. For PYY, all 16 were used; Peng Head Neck 2 was significant. For VIP, all 16 were used; Peng Head Neck 2 was significant.
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