Table 1 Relationship between ATM-p expression and clinicopathological parameters.

From: ATM kinase sustains HER2 tumorigenicity in breast cancer

Factors

ATM-p

*P value

n 167

Negative

Positive

 
 

N (%)

N (%)

 

Tumour size

 T1

42 (43.8)

54 (56.3)

0.354

 T2–T4

26 (36.6)

45 (63.4)

 

Lymph node status

 Negative

42 (46.7)

48 (53.3)

0.091

 Positive

26 (33.8)

51 (66.2)

 

Grading

 G1

10 (83.3)

2 (16.7)

0.001

 G2

37 (45.1)

45 (54.9)

 

 G3

21 (28.8)

52 (71.2)

 

Estrogen

 Negative

22 (28.9)

54 (71.1)

0.005

 Positive

46 (50.5)

45 (49.5)

 

Progesterone

 Negative

27 (32.1)

57 (67.9)

0.023

 Positive

41 (49.2)

42 (50.6)

 

HER2

 Negative

40 (50.0)

40 (50.0)

0.019

 Positive

28 (32.2)

59 (67.8)

 

Ki67

 Low

38 (58.5)

27 (41.5)

<0.001

 High

30 (30.3)

69 (69.7)

 
  1. ATM-p, ATM phosphorylation.
  2. ER/PgR negative: ≤10; ER/PgR positive: >10; HER2 negative: 0/1+/2+non-amplified; HER2 positive: 2+amplified/3+; Ki67 low: ≤15; Ki67 high: >15.
  3. *χ2-Test.