Figure 3: Frz8 inhibits LRP6-induced canonical pathway activation by the direct Frz8–LRP6 interaction. | Nature Communications

Figure 3: Frz8 inhibits LRP6-induced canonical pathway activation by the direct Frz8–LRP6 interaction.

From: LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis

Figure 3

(a) Schematic diagram of LRP6 and Frz8 deletion mutants. (b–g) TOPFLASH reporter gene assay. Deletion of the C-terminal domain of Frz8 (Frz8-ΔC) attenuated TOPFLASH activity induced by full-length LRP6 (c), LRP6-ΔE3-4LDLR (e), LRP6-ΔE1-2LDLR (f) or LRP6-ΔE1-4 (g), but not constitutively active mutant β-catenin-ΔN (b) or LRP6-ΔN (d). Values represent mean±s.d. of three experiments.

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