Figure 7: Downregulation of membrane LRP5/6 in metastases of mouse and human breast tumours.
From: LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis
(a–d) WB analysis showed lower level of membrane fraction in either or both of LRP5 and LRP6 in all lung metastases than in implanted primary 4T1 cells (a) in 92.3% of all patient lymph node metastases than in primary breast tumours (b–d). P=primary tumour; M=metastases.
