Figure 5: Intramyocardial delivery of cloned cardiac SP cells improves cardiac structure and function.
From: PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium
Views by cine-MRI are shown at end-diastole and end-systole, along with late Gadolinium (Gd)-enhanced MRI (LGE) for infarct size. (a) Representative images of mouse hearts at 1 day and 12 weeks after infarction (MI) and grafting of clones. The red bar highlights end-systolic and end-diastolic diameters. (b) Serial measurements showing improved ejection fraction and diminished infarct size at 12 weeks in infarcted hearts that received cloned cardiac SP cells. Bar graphs present the mean±s.e.m. (sham+vehicle, n=4; sham+SP cells, n=10; MI+vehicle, n=8; MI+SP cells, n=20). *P<0.05 compared with the corresponding uninfarcted control hearts; †P<0.05 compared with infarction plus the cell-free vehicle control injection.
