Table 1 TH lineage-specific lncRNAs are co-expressed with neighbouring protein-coding genes.

From: Expression and functions of long noncoding RNAs during human T helper cell differentiation

lncRNA*

Genomic position (kb)

Protein-coding

R 2 †

P value

kb away, orientation ‡

Th1

 IFNG-AS1

12:68,383–68,415 →

IFNG

0.95

<0.0001

140, Antisense

 AC007278.2

2:103,050–103,051 →

IL18R1

0.60

NS

40, sense

 (AC007278.3 adjacent to AC007278.2, also co-expressed with IL18RAP intragenic, sense)

 

IL18RAP

0.95

0.001

Intragenic, sense

  

SLC9A4

0.04

NS

34, Sense

Th2

 GATA3-AS1

10:8,092–8,095 ←

TAF3

0.03

NS

35, Sense

  

GATA3

0.87

0.007

1, Antisense

 CTD-2616J11.3

19:51,917–51,918 →

IGLON5

0.95

0.001

102, Sense

  

VSIG10L

0.95

0.0008

72, Antisense

  

ETFB

0.97

0.0004

59, Antisense

  

CLDND2

0.67

0.04

45, antisense

  

NKG7

0.11

NS

42, Sense

  

LIM2

0.01

NS

34, Antisense

  

SIGLEC10

0.98

0.0002

Intragenic, antisense

  

SIGLEC12

0.68

0.04

77, Antisense

Th17

 RP11–98D18.3

1:151,735–151,741←

SNX27

0.97

0.0003

64, Antisense

  

OAZ3

0.26

NS

Intragenic, sense

  

TDRKH

0.95

0.001

11, Sense

  

LINGO4

0.73

0.03

37, Sense

  

RORC

0.80

0.02

41, Sense

  

C2CD4D

0.84

0.001

75, Sense

  

THEM4

0.41

NS

108, Sense

 AC007182.6

14:76,041–76,045 ←

BATF

0.78

0.02

28, Antisense

  

C14orf1

0.04

NS

76, Sense

  

TTLL5

0.48

NS

81, Sense

  1. NS, non-significant.
  2. *LncRNA nomenclature, genomic positions and sense or antisense orientation were from UCSC genome browser, arrow after genomic position indicates direction of transcription.
  3. †R2 is from Pearson’s linear regression analysis, P indicates significance that the slope of the line is non-zero.
  4. kb of protein-coding gene away from lncRNA and if transcribed in sense or antisense direction relative to neighbouring lncRNA.
  5. Significant associations between expression of lncRNA and neighboring protein-coding genes are indicated by bold.
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