Figure 5: Loss of Dhh and Ihh results in defective folliculogenesis in the ovary. | Nature Communications

Figure 5: Loss of Dhh and Ihh results in defective folliculogenesis in the ovary.

From: Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells

Figure 5

(a–h) Whole mount light-field microscopic images (a,b) and histological analysis of the ovaries (c–h) from control (Sf1-Cre; Ihhf/+; Dhh+/−) and Dhh/Ihh DKO mice (Sf1-Cre; Ihhf/−; Dhh−/−) at 2 months of age. (c,d) Whole ovarian sections with different stages of follicle development. (e,f) The most advanced stage of follicle development in control (corpus luteum) and DKO ovaries (Preantral follicle). (g,h) Antral follicles from control and DKO ovaries (haemorrhagic). Asterisks indicate the presence of corpora lutea. n=7 for all control specimens and n=3 for the Dhh/Ihh DKO specimens. Scale bar, a–b, 1 mm; c–h, 200 μm.

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