Figure 3: Neutrophils are required for immunity against Nb larvae in the skin, but not in the lung. | Nature Communications

Figure 3: Neutrophils are required for immunity against Nb larvae in the skin, but not in the lung.

From: ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms

Figure 3

(a) Number of N. brasiliensis larvae in the lungs 2 days post-primary (Nb) or i.v. reinfection (Nb+Nb; reinfection infection occurs 30 days after primary infection). Neutrophils were depleted in the relevant groups with 250 μg anti-Gr1 antibody (RB6–8C5) 1 day before priming (αGr1+Nb+Nb) or one day before i.v. reinfection (Nb+αGr1+Nb; n=5 mice, mean+s.e.m., representative of two independent experiments, ANOVA). (b,c) Number of N. brasiliensis larvae in the skin (b) and lungs (c) 2 days post-s.c. primary infection or reinfection (reinfection infection occurs 4 days after primary infection). Neutrophils were depleted in the relevant groups 1 day before s.c. reinfection (n=5 mice, mean+s.e.m., representative of two independent experiments, ANOVA). NS, non-significant; ▪P<0.07; *P<0.05; ***P<0.001.

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