Figure 4: Low-dose FGF19 (10 μg) lowers plasma glucose concentrations in T1D rats by suppressing the HPA axis. | Nature Communications

Figure 4: Low-dose FGF19 (10 μg) lowers plasma glucose concentrations in T1D rats by suppressing the HPA axis.

From: FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

Figure 4

(a) Plasma corticosterone concentrations after 0–24 h of fasting in T1D rats. (b–e) Fasting plasma glucose, lactate, NEFA and glycerol concentrations. (f–h) Plasma insulin, corticosterone and ACTH concentrations. (i) Hepatic glucose production. (j) Whole-body glycolysis. (k,l) Whole-body palmitate and glycerol turnover. (m) Liver acetyl CoA. (n) Liver glycogen. Data are representative of mean±s.e.m. of n=6 per group, with comparisons by analysis of variance with Bonferroni’s multiple comparisons test.

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