Figure 4: Analysis of mutation context identifies two signatures in myeloma. | Nature Communications

Figure 4: Analysis of mutation context identifies two signatures in myeloma.

From: APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

Figure 4

(a) Mutation context identifies two signatures in myeloma, Signature A and Signature B. (b) t(14;16) and t(14;20) samples have significantly more mutations than other translocation groups. (c) The mutational context split by translocation group identifies t(14;16) and t(14;20) with more mutations which make up Signature B. (d) Stacked bar chart showing the percentage contribution of the two signatures identified by NMF in each sample, ordered by translocation group. The box and whisker plots show the 10 and 90 percentiles (whiskers) and the median and 25 and 75 percentiles (box). P values determined by analysis of variance.

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