Table 1 Loci with genome-wide association signals identified in the discovery meta-analysis.
From: Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Locus | Variant (annotation) | Chr | Position | RA | NRA | RAF | P -value | Direction | ORs | Nearby Genes | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | ||||||||||
1q31.1 | rs10789285 (intergenic) | 1 | 69,788,482 | G | T | 0.28 | 0.25 | 1.43 × 10−8 | ++++ | 1.12 | LRRC7 |
3p24.3 | rs4685408 (intronic) | 3 | 16,996,035 | G | A | 0.5 | 0.48 | 8.58 × 10−9 | ++++ | 1.12 | PLCL2 |
3q12.3 | rs7637230 (intronic) | 3 | 101,663,555 | A | G | 0.83 | 0.8 | 2.07 × 10−9 | ++++ | 1.14 | NFKBIZ |
5p13.1 | rs114934997 (intergenic) | 5 | 40,370,724 | C | A | 0.92 | 0.91 | 1.27 × 10−8 | ++++ | 1.17 | CARD6 |
10q22.2 | rs2675662 (intronic) | 10 | 75,599,127 | A | G | 0.58 | 0.56 | 7.35 × 10−9 | ++++ | 1.12 | CAMK2G |
15q25.3 | rs35343117 (intronic) | 15 | 86,079,115 | G | C | 0.37 | 0.34 | 3.10 × 10−8 | ++++ | 1.1 | AKAP13 |
