Figure 5: Fibrils formed from A488-K18 and A647- K18 tau disaggregate slowly into oligomers and monomers.
From: A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
(a) Soluble concentrations of A488-K18 were estimated using the burst rate in the donor channel from smFRET measurements. (b) The proportion of events due to oligomeric K18 decreases with incubation time, although the estimated total number of oligomers within the solution increased. (c) Three independent experiments were performed (open, filled and crossed symbols), the initial filament mass was similar but not identical in each.
