Figure 3: Mendelian randomization estimate of genetically increased T2D risk on CHD risk: subgroup analysis by physiologic cluster, computed using a random-effects model.

Shown for each SNP is mean value (black sqaure), the 95% confidence interval (black line segment) of the estimate and the inverse-variance weight (% proportional to the size of the grey square) in the random-effects meta-analysis (blue diamond). Of five biologically distinct clusters of genetic variants, only two clusters contained enough significant, non-pleiotropic variants for further analysis: (a) the cluster of variants influencing beta-cell function; and (b) the cluster unclassified variants.