Table 2 Random-effects model estimates for the effect of T2D and fasting glucose on CHD risk.

From: A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease

Instrument set

Effect size (95% CI)

P value

I2 (95% CI)

T2D (all significant SNPs, n=37)

1.11 (1.05–1.16)

1.7E−04

62.7 (46.8–73.8)

T2D (excluding pleiotropic SNPs, n=26)

1.11 (1.05–1.17)

8.8E−05

38.4 (1.2–61.6)

Fasting glucose (all significant SNPs, n=33)

1.27 (1.04–1.54)

2.0E−02

39.1 (7.3–60.0)

Fasting glucose excluding pleiotropic SNPs, n=24)

1.15 (1.00–1.32)

5.3E−02

0 (0–44.6)

  1. CHD, coronary heart disease; CI, confidence interval; MR, Mendelian randomization; SNP, single nucleotide polymorphism; T2D, type-2 diabetes.
  2. Effect size for T2D analysis is the effect on odds of CHD per odds increase in risk of T2D. Effect size for fasting glucose analysis is the effect on odds of CHD per 1 mmol l−1 increase in fasting glucose in non-diabetics. Each P value is for the MR analyses.
Back to article page