Figure 6: Summary of satellite cell contribution to adult uninjured muscle.
From: Muscle stem cells contribute to myofibres in sedentary adult mice
Pax7+ satellite cells, labelled at 6 months, contribute to myofibres in all muscles between 6 and 12 months. After 12 months, there is no appreciable satellite cell contribution in most limb muscles (TA, plantaris, soleus and EDL), but there is continued contribution in the diaphragm and EOM (also gastrocnemius, not shown). Pax7+ satellite cells are not required to maintain myofibre cross-sectional area of most muscles, but may help maintain myofibre CSA in EOM at 12 months and EDL at 20 months (red boxes). In EOM potentially Pax7−Pitx2+ (blue circles) satellite cells, as suggested by Hebert et al.45, compensate when Pax7+ satellites are ablated. Pax7+ satellite cells are shown as green circles in left panels and as brown circles in right panels.
