Figure 3: IRF9 regulates the homeostasis of memory CD8+ T cells. | Nature Communications

Figure 3: IRF9 regulates the homeostasis of memory CD8+ T cells.

From: Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells

Figure 3

(a) Frequency and absolute numbers of splenic VM CD8+ T cells in 6–8-week-old WT and IRF9−/− mice (representative groups of three independent experiments). (b) Frequency of circulating CD44+CD49dlo VM and CD44+CD49dhi TM CD8+ T cells in young (6–10 weeks) and aged (>10 month) WT and IRF9−/− mice. Representative dot plots (out of at least seven mice) and graphs are shown. (c) Expression of Eomes, CD122, CD62L, CxCR3, CD127, Bcl2 (mean fluorescence intensity (MFI)) and Ki67 (%) among CD44+CD49dlo and CD44+CD49dhi CD8+ T cells from age-matched WT and IRF9−/− old mice. For all graphs, each dot represents an individual mouse. Bars represent mean±s.e.m. *P<0.05, **P<0.01 and ***P<0.001, NS: not significant.

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