Figure 4: Genes associated with human cardiac and hepatic complex traits are under transcriptional and/or translational control.
From: Translational regulation shapes the molecular landscape of complex disease phenotypes
The SHR/Ola rat strain is an animal model for traits investigated in human GWAS studies. Genes associated with ‘heart rate’: Myh6, Gja1 and Fads1 (ref. 36), ‘metabolite levels’: Acadl, Tat37,38,60,61,62 or ‘high-density lipoprotein cholesterol’: Abca8b63,64,65 are under transcriptional and/or translational control. Representative examples of two genes for each group (RNAonly, RNA+RIBO and RIBOonly) are shown. For each gene, read counts for five biological replicates per strain across three sequencing experiments are plotted: ribosome profiling (Ribo-seq), polyA-selected RNA sequencing (RNA-seq1) and rRNA-depleted total RNA sequencing (RNA-seq2). Error bars indicate s.d. P values were corrected for multiple testing and indicate significant differences in expression (DESeq2 (ref. 45); FDR≤0.01).
