Figure 4: Top TG-associated CpG mapping to an AT-specific regulatory region—CD36. | Nature Communications

Figure 4: Top TG-associated CpG mapping to an AT-specific regulatory region—CD36.

From: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Figure 4

The top TG-associated CpG (chr7:80,276,086-80,276,087; P=1.1 × 10−9; GLM assuming a binomial distribution; turquoise track) identified in the discovery cohort maps within an intragenic region of CD36, which overlaps an AT-unique LMR (black track). Investigation within a population-based cohort (N∼650) replicated the epigenetic effect in a nearby 450K array probes (orange track); mapping to the same regulatory region (cg05917188; P=3.2 × 10−7; linear mixed model). The methylation status of the latter probe was also found to be negatively associated to CD36 expression in AT (ILMN_1665132; P=6.7 × 10−5; linear mixed model, pink track). AT-specific expression of the gene was also noted through AT RNA-Seq data (purple track).

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