Figure 1: Reduced brain volume in MAP6-KO mice associated with deficits in axonal fibre tracts. | Nature Communications

Figure 1: Reduced brain volume in MAP6-KO mice associated with deficits in axonal fibre tracts.

From: Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth

Figure 1

(a) Representative galleries of T2-weighted MRI coronal sections used to determine the whole-brain and lateral ventricle volumes from WT and MAP6-KO mice. All sections were used to determine the cerebral volumes shown in b. Sections in the yellow frame were used to determine the lateral ventricle volume shown in c. (b) Cerebral volume in WT and MAP6-KO mice. A systematic decrease of MAP6-KO mice cerebral volume in different genetic backgrounds. (c) Histogram from MRI data showing ventricle enlargement in MAP6-KO mice. (d) Representative fractional anisotropy (FA) maps of the brains of WT and MAP6-KO. Scale bar, 1 mm. (e) Histogram showing a reduction of total voxel number of MAP6-KO brain. (f) Histograms showing the voxel number distribution according to FA values (the histogram of each mouse is individually plotted). FA threshold of 0.35 is used for white matter segmentation. (g) Typical FA maps segmentation from WT mouse. Image with FA>0.35 corresponds to the white matter imaging and FA<0.35 to grey matter and ventricles. (h) Histograms of voxel numbers corresponding to FA<0.35 and FA>0.35. In all panels, number of analysed mice is between brackets. Values are given as mean±s.e.m. Percentages of change between KO and WT are indicated.. **P<0.01; ***P<0.001 (Student’s t-test).

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