Table 4 CBD GWAS SNP/transcript associations in cerebellar and temporal cortex human tissue samples.

From: Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

    

Cerebellum

Temporal cortex

SNP

Chr

Gene

Probe

Beta

P

Beta

P

rs963731

2

SOS1

ILMN_1767135

0.154

4.61 × 10−4

0.178

2.80 × 10−6

rs1768208

3

MOBP

ILMN_2298464

0.363

1.71 × 10−7

0.325

1.57 × 10−6

rs1768208

3

MOBP

ILMN_2414962

0.243

1.17 × 10−4

0.180

1.76 × 10−5

rs1768208

3

MOBP

ILMN_1768947

0.143

7.57 × 10−3

0.107

3.03 × 10−3

rs1768208

3

MOBP

ILMN_1750271

0.074

0.021

0.046

0.016

rs242557

17

MAPT

ILMN_1710903

0.183

8.80 × 10−13

0.181

1.10 × 10−8

rs242557

17

MAPT

ILMN_2298727

0.071

9.78 × 10−3

0.041

0.11

rs242557

17

MAPT

ILMN_2310814

0.002

0.83

−0.026

0.22

rs8070723

17

MAPT

ILMN_1710903

−0.473

7.02 × 10−69

−0.498

8.61 × 10−44

rs8070723

17

MAPT

ILMN_2298727

−0.173

3.36 × 10−7

−0.137

9.03 × 10−4

rs8070723

17

MAPT

ILMN_2310814

−0.007

0.58

0.018

0.37

  1. Top CBD GWAS SNPs were tested for transcript associations in 374 human cerebellum and 399 temporal cortex samples. Linear regression was employed using an additive model, with the minor allele dosage (0, 1, 2) as the independent variable, and APOE ɛ4 dosage (0, 1, 2), age at death, gender, PCR plate, RIN, (RIN-RINmean) as biological and technical covariates14.
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