Figure 1: Miscoding of mRNA during protein synthesis.
From: Structural insights into the translational infidelity mechanism
(a) The scheme depicts an event when the ribosome miscodes the phenylalanine codon by leucyl-tRNALeu, which becomes translocated to the P-site and introduces an erroneous amino acid to a polypeptide chain. A, P and E define aminoacyl, peptidyl and exit tRNA-binding sites, respectively (b,c) Schematic representations of the 70S ribosome complexes where the G·U mismatch was modelled at the first (b) or second (c) position of the codon–anticodon duplex (framed). For each complex tRNA, which was used for the complex formation is specified together with the sequence of mRNA; in mRNA-1 and mRNA-2 the Shine–Dalgarno sequence is underlined. Cognate complexes used for comparisons are indicated below each schematic representation. The first nucleotides of the mRNA codons bound in the P- and A-sites are numbered (+1) and (+4), respectively.
