Figure 10: Schematic showing structural organization of the actin nodule. | Nature Communications

Figure 10: Schematic showing structural organization of the actin nodule.

From: Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex

Figure 10

Actin nodules are an interconnected array of structures that consist of (i) a central WASp—ARP2/3 dependent actin core, which is rich in tyrosine phosphorylated proteins, (ii) a region under the core which is depleted of αIIbβ3 integrin, (iii) a ring structure containing talin and vinculin and (iv) actin filaments which radiate out to other nodules. We hypothesize that the actin polymerization-driven downward movement of the membrane (red arrow) causes the physical exclusion of integrin from the centre of the nodule. This generates tension in the actin filaments linking adjacent actin nodules (purple arrows) and so plays a mechano-sensory role important for maintaining platelet adhesion in blood flow.

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