Figure 8: A comparison of PRISM-identified SUMOylation sites and target proteins to other SUMOylation studies.

(a) STRING network analysis of all PRISM-identified SUMO target proteins. The large majority of proteins formed one core cluster at STRING confidence of ≥0.4. The size and colour of the proteins is indicative of the amount of identified SUMOylation sites. (b) Statistical data supporting the STRING network analysis. STRING clustering was performed at STRING confidences of ≥0.4 and ≥0.7, separately. Enrichment ratio is the amount of observed interactions divided by the expected interactions, as provided by the online STRING database. (c) Four-way Venn diagram comparing PRISM-identified SUMOylated proteins to SUMO target proteins identified in three other studies. (d) Four-way Venn diagram comparing PRISM-identified SUMOylated proteins to SUMO target proteins identified in a site-specific manner in three other studies. (e) Four-way Venn diagram comparing PRISM-identified SUMOylated lysines to SUMOylation sites identified in three other studies. (f) Three-way Venn diagram comparing PRISM-identified SUMOylated lysines with all known ubiquitylation and acetylation sites.