Figure 3: The effect of maternal intake of high-fibre diet and acetate on the development of AAD in the offspring. | Nature Communications

Figure 3: The effect of maternal intake of high-fibre diet and acetate on the development of AAD in the offspring.

From: Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Figure 3

(a) Pregnant mice (E13, C57Bl6) were provided with control, high-fibre diet, no-fibre diet or acetate. Offspring (female C57Bl6) were weaned onto control diet and water at 3 weeks of age and at 6 weeks, sensitized and challenged with HDM. The effect of high-fiber diet or acetate on (b) differential cell number in BALF, (c) eosinophils in blood, (d) IL-4, IL-5, IL-13, IL-10 and IFNγ release from MLN T cells, (e) serum IgE, (f) lung histology (scale bar, 200 μm), (g) eosinophils in lung tissue, (h) mucous-secreting cells (MSCs), and airway hyperresponsiveness in terms of airway resistance (RL) and dynamic compliance (Cdyn). Data represent mean+s.e.m., n=8. Significance is represented by *P<0.05, **P<0.01, ***P<0.001, Student’s t-test. One representative experiment of three is shown. ND, not detected.

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