Figure 6: The effect of acetate on HDAC activity in the lung, and the development of AAD in Hdac9−/− versus WT (C57Bl6, female) mice. | Nature Communications

Figure 6: The effect of acetate on HDAC activity in the lung, and the development of AAD in Hdac9−/− versus WT (C57Bl6, female) mice.

From: Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Figure 6

(a) HDAC activity in the whole lung (n=6). Development of AAD in Hdac9−/− versus WT mice in terms of (b) eosinophil cell number in BALF, (c) IL-5 and IL-13 release from MLN T cells, (d) serum IgE and (e) airway hyperresponsiveness in terms of airway resistance (RL). (f) Eosinophils in BALF in Hdac9+/− offspring from Hdac9−/− females crossed with WT males, in the HDM AAD model. Data represent mean+s.e.m., n=8. Significance is represented by *P<0.05, **P<0.01, ***P<0.001, Student’s t-test. One representative experiment of three is shown.

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